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NEEDLE-FREE INSULIN INJECTION TECHNOLOGY .....

InsuJet ™ is a device that can be used to administer insulin without a needle – so great for needle phobics. The insulin is fired at high pressure through a small hole, which creates a high speed jet that can penetrate the skin and underlying tissue. The pressure is generated by a powerful spring which is optimised for subcutaneous insulin delivery.

The injection technique used is just as important for glucose control of individuals as is the type and does of insulin delivered.1-5 Precise insulin dosage is an essential part of daily self-management of diabetes and there is always a risk of inappropriate administration technique.

  • 40% of users dispose of used needles inappropriately.6
  • 32% of individuals re-use needles more that 6 times potentially causing damage to both the needles and their skin.6
  • Inappropriate needle-length selection and poor skin-fold technique can increase the possibility of intramuscular injections.3

INCREASED ABSORPTION ...

InsuJet disperses insulin in the subcutaneous tissue. With needle injections, insulin is simply pushed through the skin and is more concentrated in a droplet. With Insujet, the insulin is spreads through the subcutaneous tissue in a cone-like formation maximising insulin absorption  into the circulation.

ACCELERATED UPTAKE ...

Rapid-acting insulin analogues can still take up to 30 minutes before they start working. Insulin administered by InsuJet shows activity after just 15 minutes – faster than traditional insulin injections. As this effect mimics the endogenous insulin profile (faster uptake, higher Cmax and faster drop off)7, using InsuJet may help reduce HbA1C levels. A long term study is planned to compare HbA1C in users using needles with patients using Insujet.

In a glucose clamp study, rapid-acting insulin analogues administered by InsuJet resulted in a faster onset of action and higher insulin peak values than insulin injected by conventional insulin pen. The peak  concentration of insulin administered by InsuJet was reached after just 27 minutes compared to the peak of the pen-injected insulin which was reached after 45 minutes (<0.0001).7

InsuJet

A section of pig skin showing a blue dye solution delivered subcutaneously by InsuJet.

glucose requirement glucose infusion rate GIR

INSUJET ™ VS INJECTION ...

InsuJet results in a more rapid intake of insulin compared to administration by conventional injection methods. The pharmacological profile of insulin delivered by jet injection more closely resembles the profile of endogenous insulin secretion.7

  • Consistent fast delivery of insulin to subcutaneous layer
  • No safety issues regarding disposal of needles
  • No premature withdrawal of needle
  • Suitable for needle-phobic patients
  • Predictable absorption of insulin
  • Safe, reusable consumables
  • Reduced pain

References:

1. Thow JC, Johnson AB, Fucher G, Home PD. Different absorption of Isophane (NPH) insulin from subcutaneous and intramuscular sites suggests a need to reassess recommended insulin injection technique. Diabet Med 1990; 7: 600-602.
2. Thow JC, Home PD. Insulin injection technique: depth of injection is important. BMJ 1990; 301; 3-4.

3. Frid et al. New injection recommendations for patients with diabetes. Diabet Med 2010; 36; S3 S18.
4. Strauss K et all. A pan-European epidermiologic study of insulin injection technique in patients with diabetes. Pract Diab Int 2002; 19 No 3; 71 76.
5. Bantle J , Neal L, Krankamp L. Effects of the anatomical region used for insulin injections on glycaemia in type 1 diabetes subjects. Diabetes Care 1993; 16; 1592-1597.
6. Magdalena Annersten. The Second Injection Technique Event (SITE), May 2000, Barcelona, Spain.
7. De Galan B. Improved Pharmaceutical and Pharmacodynamic, Profile of Rapid-Actin Insulin Using Needle-Free Jet Injection Technolopgy. Diabetes Care 2011; 34; 1804-1808.

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